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Biguanide (metformin) Primary mechanism(s) of action Reduces glucose production in the liver and improves liver insulin sensitivity
doi: 10.1016/j.cell.2024.07.041 [DOI] [PMC free article] [PubMed] [Google Scholar] 186.Wiciski M, Fajkiel-Madajczyk A, Kurant Z, Kurant D, Gryczka K, Falkowski M, et al
It must not be linked to another medical condition, psychiatric issue, relationship problem, or medication side effect
The resulting energy deficit manifests clinically as debilitating fatigue and post-exertional malaise (PEM), hallmark symptoms of both Long COVID and ME/CFS
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